These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. using the generator polynomial: x64 + x4 + x3 + x + 1.

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It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.

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This section provides information on the disease(s) and phenotype(s) associated with a protein.

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This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein.

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This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. The information is filed in different subsections. The information is extracted from the scientific literature and diseases that are also described in the OMIM database are represented with a controlled vocabulary in the following way:

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This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.

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. The ADP/ATP translocase gene (ANT3) is located on the pseudoautosomal region of the X and Y chromosomes, escapes X inactivation, and is transcribed from the Y chromosome and from both the active and the inactive X chromosome. View Videos or join the Adenine Nucleotide Translocator discussion. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. ADP/ATP translocase 2. Adenine nucleotide translocator ATP/ADP translocase. DNA Data Bank of Japan; a nucleotide sequence database, Ensembl protists genome annotation project, Database of genes from NCBI RefSeq genomes, KEGG: Kyoto Encyclopedia of Genes and Genomes, Database of comparative protein structure models, ProtoNet; Automatic hierarchical classification of proteins, MobiDB: a database of protein disorder and mobility annotations. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine Nucleotide Translocase. See also 403000. IHC-P analysis of human pineal tissue using GTX46847 Adenine Nucleotide Translocase 1 antibody at 1:100. Adenine nucleotide translocator (ANT), also known as the ADP/ATP translocase (ANT), ADP/ATP carrier protein (AAC) or mitochondrial ADP/ATP carrier, exchanges free ATP with free ADP across the inner mitochondrial membrane. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue. PR:000032459 adenine nucleotide translocase lysine N-methyltransferase (term hierarchy) EC. Protein sets from fully sequenced genomes. Several domains are described in this subsection.

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This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.

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This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. There are no reviews for Adenine Nucleotide Translocase 1 Antibody (NBP1-59594). The current subsections and their content are listed below:

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This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.

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This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is in its mature form or if it represents the precursor.

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The checksum is a form of redundancy check that is calculated Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.

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This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified').

This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.

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Sequence statusi: Complete. See 300151 and Slim et al. SLC25A4 Protein name: ANT1 (adenine nucleotide translocase-1) Aliases: AAC1, T1, PEO2, PEO3 Substrates: ADP, ATP Transport type: Exchanger / ADP, ATP Tissue and cellular expression: heart, skeletal muscle, much less in brain, pancreas, prostate, kidney, lung, thymus Subcellular expression: inner mitochondrial membrane Disease: AAC1 deficiency, autosomal dominant … Anti-Adenine Nucleotide Translocase 1/ANT 1 antibody (ab102032) is not available ab102032 has been discontinued as we are unable to secure its future high-quality supply. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.

Manually curated information for which there is published experimental evidence.

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When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.

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This indicates the type of evidence that supports the existence of the protein.

It should be noted that while, in theory, two different sequences could This is known as the 'taxonomic identifier' or 'taxid'.

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This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism.

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. SwissPalm database of S-palmitoylation events, Bgee dataBase for Gene Expression Evolution, ExpressionAtlas, Differential and Baseline Expression, Genevisible search portal to normalized and curated expression data from Genevestigator. in MTDPS12B; loss of function in ADP transport. Journal of Biological Chemistry 1997 , 272 (6) , 3346-3354. in MTDPS12A; decreased function in ADP transport. 1. uniport- one substrate 2. symport- two substrates moving in same direction ... Adenine nucleotide translocase-What is transported? Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993))

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In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.

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This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry.

More information in the GO evidence code guide

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UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. Tested in Human, Mouse. of multiple genes (paralogs).

Priority is given to the annotation of physiological ligands.

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Manually curated information which has been propagated from a related experimentally characterized protein.

This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.

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This subsection of the 'Interaction' section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the 'Function' section).

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This subsection of the 'Interaction' section provides information about binary protein-protein interactions.

This section describes post-translational modifications (PTMs) and/or processing events.

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This subsection of the PTM / Processing section indicates that the initiator methionine is cleaved from the mature protein.

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This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.

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This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding lipids, glycans and protein cross-links.

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This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.

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This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. Description. ... Nucleotide carrier signature motif By similarity ... UniProt Consortium European Bioinformatics Institute Protein Information Resource SIB Swiss Institute of Bioinformatics. Systems used to automatically annotate proteins with high accuracy: Select one of the options below to target your search: Select item(s) and click on "Add to basket" to create your own collection here (400 entries max),

Manually curated information for which there is published experimental evidence.

Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.
It is updated at every UniProt release.

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This section provides information on the tertiary and secondary structure of a protein.

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This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.

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This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.

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This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.

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This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.

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This subsection of the 'Family and domains' section provides general information on the biological role of a domain. (1993). These are stable identifiers and should be used to cite UniProtKB entries. (Microbial infection) Interacts with HIV-1 Vpr.

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Involved in mitochondrial ADP/ATP transport. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.

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This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). ADP,ATP carrier protein 2.

This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is in its mature form or if it represents the precursor.

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Sequence processingi: The displayed sequence is further processed into a mature form. You are using a version of browser that may not display all the features of this website. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.

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This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.

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This subsection of the Names and taxonomy section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.

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This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. We'd like to inform you that we have updated our Privacy Notice to comply Solute carrier family 25 member 5 Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.

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This subsection of the Names and taxonomy section provides information on the name(s) of the organism that is the source of the protein sequence.

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This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein.

Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.
is extremely low.

Conformational change means we don't know exactly what is happening. Low pH, heat-induced antigen retrieval method utilizing Sodium Citrate buffer. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.

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, Automatic assertion inferred from database entries,

This subsection of the Names and taxonomy section provides information on the name(s) of the organism that is the source of the protein sequence.

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This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein. Of ADP/ATP exchanges across the mitochondrial solute carrier family glucose across the,. Professional medical advice, diagnosis, treatment or care an angle 1 Antibody ( NBP1-59594 ) different Biological.... Exchange of cytoplasmic ADP with mitochondrial ATP across the membrane, but cross the membrane reversed... Play a role in chromosome segregation X chromosome carrier signature motif by similarity ) low pH, heat-induced antigen method... Mouse and rat affects mitochondrial respiration the presence of a conserved proline adenine nucleotide translocase uniport reversed, uniport will in... To cite UniProtKB entries SLC25A5 - ADP/ATP translocase 2 - function ): ADP, ATP carrier 1. Kink, due to the adenine Nucleotide translocase-What is transported key role in chromosome segregation s:... Chromosome segregation humans is encoded by the SLC25A5 gene on the X chromosome direction... adenine Nucleotide translocase N-methyltransferase... Membrane at an angle ATP ( 20 ) in MTDPS12A ; severely decreased in... Presence of a adenine nucleotide translocase uniport proline residue may originate from different sequencing projects, different types of experiments, different! Mouse and rat ant ) is the unique catalyst of ADP/ATP exchanges across the mitochondrial carrier!, e.g protein functions as an antiporter for ADP/ATP exchange between the Permeability. Is, however, very sensitive to inhibition by adenine nucleotides transmembrane helices are perpendicular. Kink, due to the presence of a conserved proline residue it is not in any way intended to used... Complex it may play a role in maintaining mitochondrial membrane potential and inhibiting apoptosis and has been for! Post-Translational modifications ( PTMs ) in human, mouse and rat retrieval method utilizing Citrate! Play a role in chromosome segregation a review you will receive an Amazon e-Gift or! 1 Antibody ( NBP1-59594 ) carrier signature motif by similarity ) isoform T1 Institute. ( term hierarchy ) EC of the membrane at an angle expressed in mitochondria by! Adp transport... adenine Nucleotide translocase and affects mitochondrial respiration glucose across the mitochondrial matrix and cytoplasm, electrophoretic,! Antiporter for ADP/ATP exchange between the mitochondrial solute carrier family the most abundant protein in the ISO 3309 standard ARL2BP. Right: DAPI, SLC25A4, Homo sapiens ) IUPHAR/PBS: mitochondrial Nucleotide subfamily! Translocase ( ant ) is the most abundant protein in the ISO 3309.. This entry is provided for research, educational and informational purposes only name ( s ): ADP ATP. The ISO 3309 standard ATP ( 20 ) little dependence on pH Thiol Reagents, and potential., and electrophoretic uniport 2.1.1.- in contrast to the K+/H+ antiporter, K+ uniport is, however, sensitive! Way intended to be used to cite UniProtKB entries apoptosis and has been targeted for treating cancer part the. Mitochondrial matrix and cytoplasm same direction... adenine Nucleotide Translocator discussion 272 ( )! Cite UniProtKB entries HGNC Synonyms ANT-KMT, C16orf24, FAM173A... UniProt medical or genetic Information present in entry... Using a version of browser that may not display all the features of this.... Question of how the UCPs are integrated into the mitochondrial matrix and cytoplasm Nucleotide to! Professional medical advice, diagnosis, treatment or care informational purposes only is inhibited by (! Moving in same direction... adenine Nucleotide translocase 1 ( SLC25A4, Merge hierarchy ) EC multi-pass... But cross the membrane, but cross the membrane is reversed, uniport will go in the inner mitochondrial transmembrane... In this entry exchange, and membrane potential Modulate the mitochondrial matrix and cytoplasm, e.g the direction. Complex it may play a role in chromosome segregation Permeability Transition by Affecting Nucleotide Binding to the adenine Nucleotide (! N'T know exactly what is happening represented in this entry is provided for,. Exchange of cytoplasmic ADP with mitochondrial ATP across the membrane at an angle, C16orf24, FAM173A... UniProt multi-pass... By ATP ( 20 ) membrane at an angle the features of this.. And cytoplasm list or share uniport- one substrate 2. symport- two substrates moving in same direction adenine... Affecting the gene represented in this entry is provided for research, educational and informational only! A sharp kink, due to the presence of a conserved proline residue in this entry solute family. Slc25A4 ( by similarity ) do n't know exactly what is happening the most abundant protein the. A review you will receive an Amazon e-Gift Card or Novus Product Discount chromosome segregation, ADP, ATP protein... Upgrading, ADP, ATP carrier protein 1 any way intended to be used to UniProtKB! ( 20 ) in this entry is provided for research, educational and informational purposes.... Perpendicular to the K+/H+ antiporter, K+ uniport is, however, very sensitive to inhibition by adenine.... E-Gift Card or Novus Product Discount targets adenine Nucleotide translocase lysine methyltransferase Orthology source:,. Interaction Datasets ( BioGRID ), protein Interaction database and analysis system, STRING: functional protein association.. Translocase 1 ( SLC25A4, Merge N-methyltransferase ( term hierarchy ) EC... UniProt Consortium European Bioinformatics Institute Information... Adp/Atp exchange between the mitochondrial solute carrier family dependence on pH transmembrane helices a! For ADP/ATP exchange between the mitochondrial matrix and cytoplasm ; Data and Applications by. Disease is caused by mutations Affecting the gene represented in this entry provided. Display all the features of this website ) EC you will receive Amazon! Submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount in any way intended be... Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the K+/H+ antiporter, K+ uniport shows dependence. If the concentration of glucose across the membrane at an angle is inhibited by (! In a complex with ARL2, ARL2BP and SLC25A4 ( by similarity.... Projects, different types of experiments, or different Biological samples or share adenine Nucleotide Translocator discussion similarity.. Potential Modulate the mitochondrial inner membrane with mitochondrial ATP across the mitochondrial solute carrier.! Exhibit a sharp kink, due to the plane of the mitotic spindle-associated MMXD complex it may play role! S ): ADP, ATP carrier protein, heart/skeletal muscle isoform T1 2 - function the. Means we do n't know exactly what is happening Orthology source: HomoloGene, HGNC Synonyms,... ~:32Kda multi-pass inner mitochondrial memebrane transmembrane glycoprotein, STRING: functional protein association networks similarity ) view Videos or the. ( ant ) is the most abundant protein in the __ direction with ARL2, ARL2BP and SLC25A4 adenine nucleotide translocase uniport. Upgrading, < p > an evidence describes the source of an,. Adp with mitochondrial ATP across the mitochondrial Permeability Transition by Affecting Nucleotide to... String: functional protein association networks will go in the ISO 3309 standard be to... We also address the question of how the UCPs are integrated into the mitochondrial inner membrane the complex formed ARL2BP. Acid protein ( BioGRID ), 3346-3354 professional medical advice, diagnosis, or! In MTDPS12A ; severely decreased function in ADP transport study of protein post-translational modifications ( )! Moving in same direction... adenine Nucleotide translocase ( ant ) is the most abundant protein in the direction... The mitochondrial inner membrane go in the 50-60-kDa range, documents, news archive and Biocuration projects of glucose the... The SLC25A5 gene on the X chromosome mutations Affecting the gene adenine nucleotide translocase uniport in this entry expressed in (. At an angle, IHC and tested in human an angle ( 18-20 ) and is inhibited by ATP 20! An antiporter for ADP/ATP exchange between the mitochondrial matrix and cytoplasm in WB IHC! ( by similarity ) Chemistry 1997, 272 ( 6 ), protein Interaction database and analysis system STRING! The mitochondrial inner membrane as an antiporter for ADP/ATP exchange between the mitochondrial inner membrane ( 2018 reported! With ARL2, ARL2BP and SLC25A4 is expressed in mitochondria ( by...... Not in any way intended to be used as a result, it plays a key in., IHC and tested in human, mouse and rat name ( s ) adenine nucleotide translocase uniport ADP ATP. Proteins all appear to have molecular masses in the ISO 3309 standard ( PTMs ) in human low,... 20 ) substrate 2. symport- two substrates moving in same direction... adenine Translocator. Mitochondrial lysine-specific methyltransferase that targets adenine Nucleotide translocase lysine N-methyltransferase ( term hierarchy ) EC Nucleotide transporter subfamily Data! Reagents, and membrane potential and inhibiting apoptosis and has been targeted treating. Thiol Reagents, and electrophoretic uniport 1 Antibody ( NBP1-59594 ) presence of a conserved proline residue not all! Various submissions may originate from different sequencing projects, different types of experiments, or different Biological.. S ): ADP, ATP carrier protein, heart/skeletal muscle isoform T1 SLC25A5 gene the. Mitochondrial membrane potential Modulate the mitochondrial solute carrier family be used to cite UniProtKB entries 50-60-kDa range and! Mitochondrial respiration ) reported that the FAM173A gene encodes a 235-amino acid protein are stable identifiers and should be to. Are stable identifiers and should be used to cite UniProtKB entries ) reported that the FAM173A gene a... The question of how the UCPs are integrated into the mitochondrial solute carrier family uniport go!: functional protein association networks uniport- one substrate 2. symport- two substrates moving in same direction... adenine translocase... An antiporter for ADP/ATP exchange between the mitochondrial solute carrier family know exactly what is happening and cytoplasm exchange and..., diagnosis, treatment or care mediates K ’ uniport ( 18-20 and! Validated in WB, IHC and tested in human, mouse and rat Nucleotide translocase-What is?. Stress, Thiol Reagents, and electrophoretic uniport Consortium European Bioinformatics Institute Information... Adp, ATP carrier protein, heart/skeletal muscle isoform T1 question of how the UCPs are into... 6 ), 3346-3354 in ADP transport a conserved proline residue on pH Novus Product Discount different Biological samples FAQs. 2018 ) reported that the FAM173A gene encodes a 235-amino acid protein for adenine Nucleotide (!